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81.
Mohanalakshmi Sabapati Narahari N. Palei Ashok Kumar C.K. Ravindra Babu Molakpogu 《Drug development and industrial pharmacy》2019,45(4):577-586
The present study was aimed to develop Annona muricata fruit extract loaded solid lipid nanoparticles (SLNs) and explore its cytotoxic potential in vitro model of breast cancers. Extract loaded SLNs were successfully prepared by high-pressure homogenization followed by ultrasonication method and optimized using 23 full factorial design. The extract loaded SLNs were characterized using different parameters such as particle size (PS), % entrapment efficiency (EE), zeta potential (ZP) and % cumulative drug release (CDR). The SLNs formulation was optimized on the basis of software analysis with an overall desirability factor. The PS and %EE of the optimized formulation were found to be 134.8?nm and 83.26%, respectively. The optimized formulation showed a CDR of 79.83% up to 48?h. In vitro cytotoxicity efficacy of extract loaded SLNs was determined using MTT and Apoptosis assay and compared to that of a free extract. The SLNs showed a notable apoptotic effect and better efficacy to kill MCF7 cancer cells as compared to free extract. Thus, extract loaded SLNs could be an alternative dosage form which possibly controls therapeutic action with reducing side effect. 相似文献
82.
Propagation characteristics of Rayleigh-type wave in a piezoelectric layered system are theoretically investigated. The piezoelectric layer is considered as a cubic crystal with finite thickness rotated about Y-axis and is imperfectly bonded onto a semi-infinite dielectric substrate. The imperfect interface between the two constituents is assumed to be mechanically compliant and dielectrically weakly conducting. The exact dispersion relations for electrically open or shorted boundary conditions are obtained. The numerical results show that the phase velocity of Rayleigh-type wave is symmetric with respect to the cut orientation of 45。 and can achieve the maximum propagation speed in this orientation. The mechanical imperfection plays an important role in the dispersion relations, further the normal imperfection can produce a significant reduction of phase velocity comparing with the tangential imperfection. Comparing with the mechanical imperfection the electrical imperfection makes a relatively small reduction of phase velocity of Rayleigh-type wave. The obtained results can provide some fundamentals for understanding of piezoelectric semiconductor and for design and application of piezoelectric surface acoustic wave devices. 相似文献
83.
潘伟强 《计算机工程与应用》2019,55(20):232-239
针对现有区间犹豫模糊Hamacher算子存在的缺陷,构建了一种基于改进的区间犹豫模糊Hamacher加权算子的群决策方法。在分析现有区间犹豫模糊Hamacher算子不能满足幂等性的基础上,定义新的区间犹豫模糊Hamacher四则运算;提出两种改进的区间犹豫模糊Hamacher加权算子,包括改进的区间犹豫模糊Hamacher有序加权平均(I-IVHFHOWA)算子和改进的区间犹豫模糊Hamacher有序加权几何(I-IVHFHOWG)算子,并详细探究它们的常用算子形式以及算子之间的内在联系;建立基于I-IVHFHOWA算子和I-IVHFHOWG算子的物流企业选择决策模型,并通过实例说明模型的有效性。 相似文献
84.
Lydia Saidi Dr. Djenisa H. A. Rocha Dr. Oualid Talhi Dr. Yamina Bentarzi Prof. Dr. Bellara Nedjar-Kolli Dr. Khaldoun Bachari Dr. Filipe A. Almeida Paz Dr. Luisa A. Helguero Prof. Dr. Artur M. S. Silva 《ChemMedChem》2019,14(10):1041-1048
Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2-hydroxybenzophenones through 1,4-conjugate addition/intramolecular cycloaddition/dehydration of nitromethane on key intermediate chromones. Structures were extensively studied by means of 2D NMR spectroscopy and single-crystal XRD. Their cytotoxicity was evaluated in vitro in two breast cancer cell lines (MDA-MB-231 and T47-D) and one prostate cancer cell line (PC3). The most potent compound exhibited good cytotoxic effects against the three cancer cell lines (IC50 values ranging from 12.09 to 26.49 μm ) and induced cell-cycle retardation only on prostate cancer cells, which suggested that it might exert cell-type-specific effects. 相似文献
85.
针对高可靠度机载多余度EWIS各组成部分寿命服从指数分布但参数未知的情况,提出采用无失效数据可靠度分析方法评估EWIS的可靠度水平。通过Monte-Carlo仿真方法对连接形式为“先并联、后串联”EWIS各组成部分寿命进行抽样,利用“最小最大值”方法获得系统寿命的抽样值,用概率纸检验法初步判断EWIS寿命是否服从威布尔分布,再用Pearson拟合优度检验法判断EWIS寿命是否服从威布尔分布。结合无故障飞行时间的样本值与EWIS寿命服从威布尔分布的假设,采用无失效数据分析方法评估EWIS的可靠度水平。研究方法对机载多余度EWIS无失效数据可靠度分析有一定的贡献。 相似文献
86.
Hitoshi Muta 《Journal of Nuclear Science and Technology》2019,56(5):367-368
Recent activities in the field of Nuclear Operational Management and Nuclear Safety Engineering, the studies related to risk analysis methodology, design, and operational management, physical phenomena, and emergency preparedness and nuclear security, have been progressed. Especially, ‘risk analysis methodology’ and ‘design and operational management’ are the main categories of the field, in which more than half of published articles on Journal of Nuclear Science and Technology are related to these categories. 相似文献
87.
88.
The changeable structure and movement law of overlying strata are the main contributor to the change of mining stress. Starting from the relevant theory of key stratum and particularly based on the theory of mine ground pressure and strata control, this research proposed a new solution to mining stress problems by establishing a dual-load-zone stratum structural model. Elastic foundation beam theory was used to solve the stress of overlying strata of the dual-load-zones with superposition method, which revised the traditional calculation method of mining stress. The abnormal increase of lead abutment pressure in the mining area was explained effectively, through which the evolution law of mining stress in the case of hard rock was obtained. The results indicate that mining stress experiences a drastic change within the range of 50 m ahead of the coal wall due to the collapse of main roof; under the influence of main key stratum and inferior key strata, the influence range of lead abutment pressure is extended up to approximately 120 m in the working face; this remarkable increase can be attributed to the excessive length of sagging zone. Results from both the dual-load-zone model experiment and field measurement demonstrate high consistency. The model can predict the influence range of abutment pressure effectively and thus guide the safety production of mining. 相似文献
89.
Degree based topological indices are being widely used in computer-aided modeling, structural activity relations, and drug designing to predict the underlying topological properties of networks and graphs. In this work, we compute the certain important degree based topological indices like Randic index, sum connectivity index, ABC index, ABC4 index, GA index and GA5 index of Book graph Bn and Stacked book graph Bm,n. The results are analyzed by using edge partition, and the general formulas are derived for the above-mentioned families of graphs. 相似文献
90.
Muhammad Shoaib Arif Ali Raza Muhammad Rafiq Mairaj Bibi Rabia Fayyaz Mehvish Naz Umer Javed 《计算机、材料和连续体(英文)》2019,59(3):787-804
In this paper, a reliable stochastic numerical analysis for typhoid fever incorporating with protection against infection has been considered. We have compared the solutions of stochastic and deterministic typhoid fever model. It has been shown that the stochastic typhoid fever model is more realistic as compared to the deterministic typhoid fever model. The effect of threshold number T* hold in stochastic typhoid fever model. The proposed framework of the stochastic non-standard finite difference scheme (SNSFD) preserves all dynamical properties like positivity, bounded-ness and dynamical consistency defined by Mickens, R. E. The stochastic numerical simulation of the model showed that increase in protection leads to low disease prevalence in a population. 相似文献